Study looks at low dose aspirin and its effect on pregnancy in women who had pregnancy loss

Researchers in the Department of Obstetrics and Gynecology at the University of Colorado Denver School of Medicine want to know if low doses of aspirin can help a woman conceive, maintain the pregnancy and deliver a healthy baby.

The EAGeR (Effects of Aspirin in Gestation and Reproduction) Study will look at women who have had a pregnancy loss in the past and want to become pregnant again. The overall goal is to evaluate the effects of low dose aspirin on reproduction, specifically on conception and pregnancy among women who have had a previous pregnancy loss. Low dose aspirin is attractive as a therapy for reproductive disorders because of its high safety profile. EAGeR will evaluate the effects of low dose aspirin taken before pregnancy through 36 weeks gestation.

EAGeR will compare the incidence of live births in women who receive low dose aspirin compared to women who receive placebo. Study participants must have had one or two pregnancy losses and be interested in becoming pregnant again. Once a participant becomes pregnant, she can continue to see her chosen healthcare provider and deliver her baby at the hospital of her choice while still participating in the study.

The possibility that low dose aspirin could improve pregnancy outcomes is important according to the Principal Investigator Anne Lynch, MD, MSPH, “Low dose aspirin may increase blood flow to the uterus and also to the placenta, increasing food and oxygen to the baby. Participants in this study will not only be advancing research but potentially improving their own chances of a healthy pregnancy.”

Lynch goes on to say: “The Denver EAGeR research team consists of caring individuals who understand the pain of pregnancy loss.” EAGeR is a national study with research taking place at the University of Utah, State University of New York at Buffalo and Commonwealth Medical College in Scranton, Pennsylvania.

If you are between 18-40 years old, have had a pregnancy loss and want to become pregnant again, you may qualify for this study. For more information, please visit the trial website at: call 303.724.3525 or email [email protected].

The University of Colorado Denver School of Medicine faculty work to advance science and improve care as the physicians, educators and scientists at University of Colorado Hospital, The Children’s Hospital, Denver Health, National Jewish Health, and the Denver Veterans Affairs Medical Center. Degrees offered by the CU Denver School of Medicine include doctor of medicine, doctor of physical therapy, and masters of physician assistant studies. The School is part of the University of Colorado Denver, one of three campuses in the University of Colorado system.

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